Appendicitis Research Today is a free monthly online journal that collates and summarizes the latest research about Appendicitis, including details on symptoms, surgery, causes, treatment.

Is early analgesia associated with delayed treatment of appendicitis?

Frei SP, Bond WF, Bazuro RK, Richardson DM, Sierzega GM, Wasser TE

Emergency Department, Lehigh Valley Hospital-Muhlenberg, Bethlehem, PA 18017, USA. steven.frei@lvh.com

PURPOSE: We sought to investigate the relationship between delay in treatment of appendicitis and early use of analgesia. BASIC PROCEDURES: We designed a matched case-control study, with patients having delayed treatment of appendicitis as the cases and patients with no delay in treatment of appendicitis as controls matched for age, sex, Alvarado score, and date of diagnosis. Of 957 patients with appendicitis, there were 103 delayed cases. Matching patients were identified yielding 103 controls. MAIN FINDINGS: In comparing cases and controls for early opiate use (26/103 cases, 24/103 controls), there was no association with delayed treatment (odds ratio, 1.11; P = .745; 95% confidence interval, 0.59-3.89). When comparing cases and controls for early NSAID use (29/103 cases, 17/103 controls), an association was found with delayed treatment (odds ratio, 1.98; P = .045; 95% confidence interval, 1.01-3.89). CONCLUSION: For early analgesia in appendicitis, we did not find an association with delayed treatment for opiate analgesia, but there did appear to be an association with nonsteroidal anti-inflammatory analgesia.

Published 14 February 2008 in Am J Emerg Med, 26(2): 176-80.
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